[15] Real Santa Cruz 4-1 Real Potosí [13] 2021-05-12 19:00
Estadio: Estadio Juan Carlos Duran Round: 5
Head to Head
| Bolivia - Torneo Apertura | 2020/12/09 19:00 | Real Santa Cruz v Real Potosí | W | 3-1 |
| Bolivia - Torneo Apertura | 2020/02/02 21:15 | Real Potosí v Real Santa Cruz | L | 2-1 |
Home History
| Bolivia - Torneo Apertura | 2021/05/07 19:00 | Real Santa Cruz v Blooming Santa Cruz | W | 1-0 |
| Bolivia - Torneo Apertura | 2021/05/01 23:30 | Guabira v Real Santa Cruz | L | 1-0 |
| Bolivia - Torneo Apertura | 2021/04/09 19:00 | Royal Pari FC v Real Santa Cruz | L | 3-2 |
| Bolivia - Torneo Apertura | 2021/04/03 19:00 | Real Santa Cruz v Always Ready | L | 2-3 |
| Bolivia - Torneo Apertura | 2021/03/28 19:00 | Real Santa Cruz v Jorge Wilstermann | L | 0-2 |
| Bolivia - Torneo Apertura | 2021/03/13 23:30 | Atlético Palmaflor Vinto v Real Santa Cruz | L | 1-0 |
| Bolivia - Torneo Apertura | 2020/12/31 19:00 | Club Aurora v Real Santa Cruz | D | 1-1 |
| Bolivia - Torneo Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
Away History
| Bolivia - Torneo Apertura | 2021/05/09 23:30 | Oriente Petrolero v Real Potosí | L | 2-0 |
| Bolivia - Torneo Apertura | 2021/05/02 19:00 | Real Potosí v Nacional Potosí | L | 1-2 |
| Bolivia - Torneo Apertura | 2021/04/11 23:30 | Real Potosí v San José | W | 3-0 |
| Bolivia - Torneo Apertura | 2021/04/02 00:00 | Real Tomayapo v Real Potosí | D | 0-0 |
| Bolivia - Torneo Apertura | 2021/03/21 23:30 | Bolívar v Real Potosí | L | 1-0 |
| Bolivia - Torneo Apertura | 2021/03/16 00:00 | Real Potosí v Club Aurora | D | 1-1 |
| Bolivia - Torneo Apertura | 2020/12/31 19:00 | Guabira v Real Potosí | L | 4-0 |
| Bolivia - Torneo Apertura | 2020/12/29 19:00 | Real Potosí v Nacional Potosí | L | 2-3 |