| NCAAF | 11/17 00:00 | 1 | [48] Nicholls Colonels v Southeastern Louisiana Lions [100] | L | 21-16 | |
| NCAAF | 11/11 21:30 | 1 | [108] Southeastern Louisiana Lions v Texas A&M-Commerce [117] | W | 52-14 | |
| NCAAF | 11/04 20:00 | 1 | McNeese State Cowboys v Southeastern Louisiana Lions | W | 24-38 | |
| NCAAF | 10/20 00:00 | 1 | Southeastern Louisiana Lions v Northwestern State | W | 37-20 | |
| NCAAF | 10/14 20:00 | 1 | Lamar Cardinals v Southeastern Louisiana Lions | L | 30-24 | |
| NCAAF | 10/07 21:00 | 1 | Southeastern Louisiana Lions v Incarnate Word | L | 26-33 | |
| NCAAF | 09/30 20:00 | 1 | Tarleton State v SE Louisiana Lions | L | 14-13 | |
| NCAAF | 09/23 23:00 | 1 | Houston Christian v Southeastern Louisiana Lions | L | 34-19 | |
| NCAAF | 09/16 20:00 | 1 | Southeastern Louisiana Lions v Eastern Washington | L | 29-40 | |
| NCAAF | 09/09 21:00 | 1 |
[110] Southeastern Louisiana Lions
v
South Alabama
[110] 
|
L | 17-35 | |
| NCAAF | 09/02 20:00 | 1 |
[20] SE Louisiana Lions
v
Mississippi State
[29] 
|
L | 7-48 | |
| NCAAF | 12/03 20:00 | 8 | Southeastern Louisiana Lions v Samford Bulldogs | L | 42-48 | |
| NCAAF | 11/27 00:00 | 1 |
Idaho
v
Southeastern Louisiana Lions
|
W | 42-45 | |
| NCAAF | 11/18 00:00 | 1 | Southeastern Louisiana Lions v Nicholls Colonels | W | 40-17 | |
| NCAAF | 11/12 22:00 | 1 | Northwestern State v SE Louisiana Lions | W | 7-23 | |
| NCAAF | 11/05 20:00 | 1 | Southeastern Louisiana Lions v Lamar Cardinals | W | 47-31 | |
| NCAAF | 10/30 00:00 | 1 | Southeastern Louisiana Lions v McNeese State Cowboys | W | 28-27 | |
| NCAAF | 10/22 18:00 | 1 | Southeastern Louisiana Lions v Jacksonville State | W | 31-14 | |
| NCAAF | 10/08 21:00 | 1 | [68] Texas A&M-Commerce v SE Louisiana Lions [39] | L | 31-28 | |
| NCAAF | 10/01 23:00 | 1 | Murray State Racers v SE Louisiana Lions | W | 14-48 | |
| NCAAF | 09/24 23:00 | 1 | Incarnate Word v Southeastern Louisiana Lions | W | 35-41 | |
| NCAAF | 09/17 23:00 | 1 | [92] Central Connecticut v Southeastern Louisiana Lions [101] | W | 6-70 | |
| NCAAF | 09/10 22:00 | 1 |
[82] SE Louisiana Lions
v
Florida Atlantic
[1] 
|
L | 9-42 | |
| NCAAF | 09/03 23:00 | 1 | [31] Southeastern Louisiana Lions v UL Lafayette [50] | L | 7-24 | |
| NCAAF | 12/04 19:00 | 1 | SE Louisiana Lions v James Madison | L | 20-59 | |
| NCAAF | 11/28 00:00 | 1 | Florida A&M v Southeastern Louisiana Lions | W | 14-38 | |
| NCAAF | 11/19 00:00 | 1 | [60] Nicholls Colonels v SE Louisiana Lions [17] | L | 45-42 | |
| NCAAF | 11/14 00:00 | 1 | Northwestern State v SE Louisiana Lions | W | 28-56 | |
| NCAAF | 11/06 19:00 | 1 | SE Louisiana Lions v Incarnate Word | L | 52-55 | |
| NCAAF | 10/30 23:00 | 1 | McNeese State Cowboys v SE Louisiana Lions | W | 20-23 |