Estadio: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Sterlin Gilbert
| NCAAF | 2018/09/15 23:00 | Nicholls Colonels v McNeese State Cowboys | W | 10-20 |
| NCAAF | 2017/09/01 00:00 | Nicholls Colonels v McNeese State Cowboys | L | 37-35 |
| NCAAF | 2019/11/02 21:00 | Northwestern State v McNeese State Cowboys | W | 20-30 |
| NCAAF | 2019/10/26 20:00 | McNeese State Cowboys v Stephen F. Austin Lumberjacks | W | 33-10 |
| NCAAF | 2019/10/19 21:00 | Houston Christian v McNeese State Cowboys | W | 27-42 |
| NCAAF | 2019/10/12 21:00 | McNeese State Cowboys v Central Arkansas | L | 31-40 |
| NCAAF | 2019/10/05 21:00 | SE Louisiana Lions v McNeese State Cowboys | W | 34-38 |
| NCAAF | 2019/09/28 23:00 | Sam Houston State Bearkats v McNeese State Cowboys | L | 28-17 |
| NCAAF | 2019/09/21 23:00 | McNeese State Cowboys v Abilene Christian | L | 10-17 |
| NCAAF | 2019/09/14 23:00 | Alcorn State v McNeese State Cowboys | W | 14-17 |
| NCAAF | 2019/11/09 21:00 | Houston Christian v Nicholls Colonels | W | 27-48 |
| NCAAF | 2019/11/02 21:00 | Nicholls Colonels v Incarnate Word | W | 27-23 |
| NCAAF | 2019/10/26 20:00 | Abilene Christian v Nicholls Colonels | L | 37-31 |
| NCAAF | 2019/10/19 19:00 | Nicholls Colonels v Sam Houston State Bearkats | L | 0-17 |
| NCAAF | 2019/10/12 20:00 | Northwestern State v Nicholls Colonels | W | 35-45 |
| NCAAF | 2019/10/05 20:00 | Central Arkansas v Nicholls Colonels | W | 14-34 |
| NCAAF | 2019/09/28 23:00 | Nicholls Colonels v Texas State | L | 3-24 |
| NCAAF | 2019/09/21 23:00 | Nicholls Colonels v Stephen F. Austin Lumberjacks | W | 48-30 |