[3] El Zamalek 0-1 Esperance de Tunis [1] 2021-03-16 19:00
Estadio: Internacional de El Cairo Round: 4
Head to Head
| CAF - Champions League | 2021/03/06 16:00 | Esperance de Tunis v El Zamalek | L | 3-1 |
| CAF - Champions League | 2020/03/06 19:00 | Esperance de Tunis v El Zamalek | L | 1-0 |
| CAF - Champions League | 2020/02/28 16:00 | El Zamalek v Esperance de Tunis | W | 3-1 |
| Supercopa de la CAF | 2020/02/14 16:00 | Esperance de Tunis v El Zamalek | W | 1-3 |
Home History
| Egipto - 1ª división | 2021/03/11 17:30 | El Zamalek v Ceramica Cleopatra | W | 2-0 |
| CAF - Champions League | 2021/03/06 16:00 | Esperance de Tunis v El Zamalek | L | 3-1 |
| Egipto - 1ª división | 2021/03/01 17:30 | Wadi Degla v El Zamalek | D | 0-0 |
| CAF - Champions League | 2021/02/23 16:00 | Teungueth FC v El Zamalek | D | 0-0 |
| Egipto - 1ª división | 2021/02/17 17:30 | El Zamalek v Ismaily SC | W | 2-1 |
| CAF - Champions League | 2021/02/12 19:00 | El Zamalek v MC Alger | D | 0-0 |
| Egipto - 1ª división | 2021/02/07 17:30 | El Zamalek v Al Ittihad Al Sakandary | W | 2-0 |
| Egipto - 1ª división | 2021/02/02 15:00 | Ghazl El Mahallah v El Zamalek | L | 2-1 |
Away History
| Túnez - CPL-1 | 2021/03/13 13:00 | Etoile Sportive Sahel v Esperance de Tunis | L | 2-0 |
| Túnez - CPL-1 | 2021/03/10 13:00 | Esperance de Tunis v US Ben Guerdane | W | 1-0 |
| CAF - Champions League | 2021/03/06 16:00 | Esperance de Tunis v El Zamalek | W | 3-1 |
| Túnez - CPL-1 | 2021/02/27 13:00 | AS Soliman v Esperance de Tunis | W | 0-2 |
| CAF - Champions League | 2021/02/23 19:00 | MC Alger v Esperance de Tunis | D | 1-1 |
| Túnez - CPL-1 | 2021/02/17 13:00 | JS Kairouanaise v Esperance de Tunis | W | 0-3 |
| CAF - Champions League | 2021/02/13 13:00 | Esperance de Tunis v Teungueth FC | W | 2-1 |
| Túnez - CPL-1 | 2021/02/07 12:00 | ES Metlaoui v Esperance de Tunis | W | 1-2 |