[4] Dominic Thiem 3-6,6-3,6-4 John Isner [39] 2021-05-07 11:00
Estadio: Manolo Santana Stadium Round: 27 Ground: Clay
Head to Head
| Laver Cup | 2017/09/22 13:10 | Dominic Thiem v John Isner | 6-7,7-6,10-7 |
Home History
| ATP Madrid | 2021/05/06 09:00 | Dominic Thiem v Alex De Minaur | 7-6,6-4 |
| ATP Madrid | 2021/05/04 17:20 | Dominic Thiem v Marcos Giron | 6-1,6-3 |
| ATP Dubái | 2021/03/16 17:10 | Dominic Thiem v Lloyd Harris | 3-6,4-6 |
| ATP Doha | 2021/03/11 17:45 | Dominic Thiem v Roberto Bautista-Agut | 6-7,6-2,4-6 |
| ATP Doha | 2021/03/10 13:00 | Dominic Thiem v Aslan Karatsev | 6-7,6-3,6-2 |
| Open de Australia | 2021/02/14 04:50 | Dominic Thiem v Grigor Dimitrov | 4-6,4-6,0-6 |
| Open de Australia | 2021/02/12 08:05 | Dominic Thiem v Nick Kyrgios | 4-6,4-6,6-3,6-4,6-4 |
| Open de Australia | 2021/02/10 04:10 | Dominic Thiem v Dominik Koepfer | 6-4,6-0,6-2 |
Away History
| ATP Madrid | 2021/05/06 13:20 | John Isner v Andrey Rublev | 7-6,3-6,7-6 |
| ATP Madrid | 2021/05/05 16:00 | Roberto Bautista-Agut v John Isner | 4-6,7-6,6-7 |
| ATP Madrid | 2021/05/03 09:00 | John Isner v Miomir Kecmanovic | 6-4,7-6 |
| ATP Miami | 2021/03/30 15:00 | John Isner v Roberto Bautista-Agut | 3-6,6-4,6-7 |
| ATP Miami | 2021/03/28 15:00 | Felix Auger Aliassime v John Isner | 6-7,6-7 |
| ATP Miami | 2021/03/27 01:05 | Mackenzie McDonald v John Isner | 6-2,3-6,5-7 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP Acapulco | 2021/03/16 01:20 | John Isner v Salvatore Caruso | 6-4,6-3 |