[6] Club Olimpia 1-3 River Plate Asuncion [7] 2021-07-18 21:15
Estadio: Estadio Manuel Ferreira Round: 1
Árbitro: Carlos P. Benitez Home Manager: Sergio Daniel Orteman Rodriguez Away Manager: Celso Ayala
Head to Head
| Paraguay - Primera División | 2021/05/30 21:45 | River Plate Asuncion v Club Olimpia | W | 1-2 |
| Paraguay - Primera División | 2021/03/21 23:30 | Club Olimpia v River Plate Asuncion | W | 5-1 |
| Paraguay - Primera División | 2020/11/28 22:00 | Club Olimpia v River Plate Asuncion | W | 3-1 |
| Paraguay - Primera División | 2020/09/11 23:30 | River Plate Asuncion v Club Olimpia | W | 0-4 |
| Paraguay - Primera División | 2020/03/08 23:15 | Club Olimpia v River Plate Asuncion | D | 1-1 |
| Paraguay - Primera División | 2019/10/19 23:15 | River Plate Asuncion v Club Olimpia | W | 0-1 |
| Paraguay - Primera División | 2019/07/27 22:00 | Club Olimpia v River Plate Asuncion | W | 2-1 |
| Paraguay - Primera División | 2019/05/14 19:00 | River Plate Asuncion v Club Olimpia | D | 2-2 |
Home History
| Copa Libertadores - Clasificación | 2021/07/16 00:30 | Club Olimpia v Internacional | D | 0-0 |
| Paraguay - Primera División | 2021/05/30 21:45 | River Plate Asuncion v Club Olimpia | W | 1-2 |
| Copa Libertadores | 2021/05/26 22:00 | Club Olimpia v Deportivo Táchira | W | 6-2 |
| Paraguay - Primera División | 2021/05/23 21:45 | Club Olimpia v Sportivo Luqueño | W | 4-1 |
| Copa Libertadores | 2021/05/21 00:00 | Club Olimpia v Internacional | L | 0-1 |
| Paraguay - Primera División | 2021/05/17 22:00 | Club Nacional v Club Olimpia | L | 2-1 |
| Copa Libertadores | 2021/05/14 00:00 | Always Ready v Club Olimpia | W | 1-2 |
| Paraguay - Primera División | 2021/05/09 21:45 | Club Olimpia v Sol de América | D | 3-3 |
Away History
| Paraguay - Primera División | 2021/05/30 21:45 | River Plate Asuncion v Club Olimpia | L | 1-2 |
| Copa Sudamericana | 2021/05/27 00:30 | Corinthians v River Plate Asuncion | L | 4-0 |
| Paraguay - Primera División | 2021/05/24 00:00 | Club Nacional v River Plate Asuncion | W | 0-1 |
| Copa Sudamericana | 2021/05/18 22:15 | River Plate Asuncion v Peñarol | W | 2-1 |
| Paraguay - Primera División | 2021/05/16 21:45 | River Plate Asuncion v Cerro Porteño | D | 1-1 |
| Copa Sudamericana | 2021/05/14 00:30 | River Plate Asuncion v Sport Huancayo | W | 2-1 |
| Paraguay - Primera División | 2021/05/10 00:00 | Guaireña FC v River Plate Asuncion | D | 0-0 |
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | L | 3-0 |