[1] Club América 2-0 Mazatlán F.C. [12] 2021-09-12 02:00
Estadio: Estadio Azteca Round: 8
Árbitro: Diego Montano Robles Home Manager: Santiago Solari Away Manager: Benat San Jose
Head to Head
| México - Liga MX | 2021/03/20 03:00 | Mazatlán F.C. v Club América | W | 0-1 |
| México - Liga MX | 2020/09/03 01:00 | Club América v Mazatlán F.C. | W | 3-1 |
| Europa - Amistosos | 2018/07/08 23:30 | Mazatlán F.C. v Club América | W | 1-2 |
| México - Liga MX | 2016/08/14 02:00 | Club América v Mazatlán F.C. | D | 1-1 |
| México - Liga MX | 2016/03/05 23:00 | Club América v Mazatlán F.C. | W | 4-1 |
| México - Liga MX | 2015/09/20 01:30 | Mazatlán F.C. v Club América | W | 0-3 |
| México - Liga MX | 2015/02/07 01:30 | Mazatlán F.C. v Club América | D | 2-2 |
| México - Liga MX | 2014/08/16 22:00 | Club América v Mazatlán F.C. | W | 3-2 |
Home History
| México - Liga MX | 2021/08/29 02:00 | León v Club América | D | 1-1 |
| México - Liga MX | 2021/08/22 22:00 | Club América v Tijuana | W | 2-0 |
| México - Liga MX | 2021/08/19 02:00 | Juárez FC v Club América | W | 1-2 |
| México - Liga MX | 2021/08/15 22:00 | Atlas v Club América | W | 0-1 |
| CONCACAF - Copa de Campeones | 2021/08/13 02:00 | Club América v Philadelphia Union | W | 2-0 |
| México - Liga MX | 2021/08/08 00:00 | Club América v Puebla | W | 2-0 |
| México - Liga MX | 2021/08/01 00:00 | Club América v Necaxa | W | 2-1 |
| México - Liga MX | 2021/07/23 02:00 | Querétaro v Club América | D | 0-0 |
Away History
| México - Liga MX | 2021/08/28 00:00 | Mazatlán F.C. v Atlético San Luis | D | 2-2 |
| México - Liga MX | 2021/08/21 02:00 | Mazatlán F.C. v Tigres UANL | L | 0-3 |
| México - Liga MX | 2021/08/17 22:00 | Toluca v Mazatlán F.C. | D | 2-2 |
| México - Liga MX | 2021/08/15 00:00 | León v Mazatlán F.C. | L | 3-0 |
| México - Liga MX | 2021/08/07 00:00 | Mazatlán F.C. v Monterrey | D | 1-1 |
| México - Liga MX | 2021/07/31 00:00 | Mazatlán F.C. v Pachuca | W | 2-1 |
| México - Liga MX | 2021/07/27 01:00 | Cruz Azul v Mazatlán F.C. | W | 0-2 |
| México - Liga MX | 2021/05/02 02:06 | Monterrey v Mazatlán F.C. | L | 1-0 |