[18] Santa Clara 0-3 Oporto [1] 2021-11-07 17:00
Estadio: Estadio de Sao Miguel Round: 11
Árbitro: Rui Costa Home Manager: Nuno Campos Away Manager: Sérgio Conceicao
Head to Head
| Portugal - Copa de la Liga | 2021/10/26 18:00 | Santa Clara v Oporto | W | 3-1 |
| Portugal - Primeira Liga | 2021/04/03 19:30 | Oporto v Santa Clara | L | 2-1 |
| Portugal - Primeira Liga | 2020/11/28 18:00 | Santa Clara v Oporto | L | 0-1 |
| Portugal - Primeira Liga | 2020/03/02 19:30 | Santa Clara v Oporto | L | 0-2 |
| Copa de Portugal | 2019/12/19 19:15 | Oporto v Santa Clara | L | 1-0 |
| Portugal - Copa de la Liga | 2019/09/25 20:00 | Oporto v Santa Clara | L | 1-0 |
| Portugal - Primeira Liga | 2019/09/22 19:30 | Oporto v Santa Clara | L | 2-0 |
| Portugal - Primeira Liga | 2019/04/20 19:30 | Oporto v Santa Clara | L | 1-0 |
Home History
| Portugal - Primeira Liga | 2021/10/31 18:00 | Belenenses v Santa Clara | L | 2-1 |
| Portugal - Copa de la Liga | 2021/10/26 18:00 | Santa Clara v Oporto | W | 3-1 |
| Portugal - Primeira Liga | 2021/10/23 14:30 | Santa Clara v FC Famalicão | L | 0-2 |
| Copa de Portugal | 2021/10/16 15:00 | UD Leiria v Santa Clara | W | 0-2 |
| Portugal - Primeira Liga | 2021/10/02 14:30 | Vizela v Santa Clara | D | 1-1 |
| Portugal - Primeira Liga | 2021/09/26 17:00 | Santa Clara v Braga | D | 1-1 |
| Portugal - Copa de la Liga | 2021/09/22 18:00 | Rio Ave v Santa Clara | D | 2-2 |
| Portugal - Primeira Liga | 2021/09/17 19:15 | Portimonense v Santa Clara | L | 2-1 |
Away History
| UEFA Champions League | 2021/11/03 17:45 | AC Milan v Oporto | D | 1-1 |
| Portugal - Primeira Liga | 2021/10/30 16:00 | Oporto v Boavista | W | 4-1 |
| Portugal - Copa de la Liga | 2021/10/26 18:00 | Santa Clara v Oporto | L | 3-1 |
| Portugal - Primeira Liga | 2021/10/23 17:00 | CD Tondela v Oporto | W | 1-3 |
| UEFA Champions League | 2021/10/19 19:00 | Oporto v AC Milan | W | 1-0 |
| Copa de Portugal | 2021/10/15 17:45 | SU Sintrense v Oporto | W | 0-5 |
| Portugal - Primeira Liga | 2021/10/02 17:00 | Oporto v Paços de Ferreira | W | 2-1 |
| UEFA Champions League | 2021/09/28 19:00 | Oporto v Liverpool | L | 1-5 |