[110] Illinois 20-18 Penn State [23] 2021-10-23 16:00
Estadio: Beaver Stadium Round: 1
Home Manager: James Franklin Away Manager: Bret Bielema
Head to Head
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | L | 21-56 |
| NCAAF | 2018/09/22 01:00 | Penn State v Illinois | L | 63-24 |
| NCAAF | 2015/10/31 16:00 | Penn State v Illinois | L | 39-0 |
| NCAAF | 2014/11/22 17:00 | Illinois v Penn State | W | 16-14 |
| NCAAF | 2012/09/29 12:00 | Illinois v Penn State | L | 7-35 |
| NCAAF | 2011/10/29 12:00 | Penn State v Illinois | L | 10-7 |
| NCAAF | 2010/10/09 12:00 | Penn State v Illinois | W | 13-33 |
| NCAAF | 2008/09/27 12:00 | Penn State v Illinois | L | 38-24 |
Home History
| NCAAF | 2021/10/09 19:30 | Wisconsin v Illinois | L | 24-0 |
| NCAAF | 2021/10/02 16:00 | Charlotte v Illinois | W | 14-24 |
| NCAAF | 2021/09/25 19:30 | Illinois v Purdue | L | 9-13 |
| NCAAF | 2021/09/18 01:00 | Maryland v Illinois | L | 20-17 |
| NCAAF | 2021/09/11 15:00 | Illinois v Virginia | L | 14-42 |
| NCAAF | 2021/09/04 23:30 | Texas-San Antonio v Illinois | L | 37-30 |
| NCAAF | 2021/08/28 17:00 | Nebraska v Illinois | W | 22-30 |
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | L | 21-56 |
Away History
| NCAAF | 2021/10/09 20:00 | Penn State v Iowa | L | 20-23 |
| NCAAF | 2021/10/02 23:30 | Indiana v Penn State | W | 0-24 |
| NCAAF | 2021/09/25 16:00 | Villanova Wildcats v Penn State | W | 17-38 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | W | 20-28 |
| NCAAF | 2021/09/11 19:30 | Ball State v Penn State | W | 13-44 |
| NCAAF | 2021/09/04 16:00 | Penn State v Wisconsin | W | 16-10 |
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | W | 21-56 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | W | 24-39 |