Estadio: Five Star Stadium Round: 1
Home Manager: Drew Cronic Away Manager: Chris Hatcher
| NCAAF | 2021/04/17 17:00 | Mercer v Samford Bulldogs | W | 20-44 |
| NCAAF | 2019/11/02 23:00 | Samford Bulldogs v Mercer | L | 33-36 |
| NCAAF | 2018/09/15 19:00 | Mercer v Samford Bulldogs | L | 30-24 |
| NCAAF | 2017/11/04 19:00 | Mercer v Samford Bulldogs | W | 3-20 |
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford Bulldogs | L | 55-48 |
| NCAAF | 2021/09/18 18:30 | Samford Bulldogs v Western Carolina | W | 42-37 |
| NCAAF | 2021/09/11 23:00 | Samford Bulldogs v Tennessee Martin | L | 27-33 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford Bulldogs | W | 14-52 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford Bulldogs | W | 20-44 |
| NCAAF | 2021/03/27 17:00 | Samford Bulldogs v The Citadel | W | 55-7 |
| NCAAF | 2021/03/20 17:00 | VMI v Samford Bulldogs | L | 38-37 |
| NCAAF | 2021/03/13 18:00 | Wofford v Samford Bulldogs | W | 31-37 |
| NCAAF | 2021/09/25 18:00 | Mercer v Furman | W | 24-3 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | L | 14-48 |
| NCAAF | 2021/09/02 23:00 | Mercer v Point University Skyhawks | W | 69-0 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford Bulldogs | L | 20-44 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | W | 13-21 |
| NCAAF | 2021/04/03 19:30 | Furman v Mercer | W | 14-26 |
| NCAAF | 2021/03/27 16:00 | Mercer v Tennessee Chattanooga | W | 35-28 |
| NCAAF | 2021/03/20 20:00 | Mercer v Western Carolina | W | 45-28 |