[61] East Carolina 16-20 Central Florida [80] 2021-10-09 22:00
Estadio: Spectrum Stadium Round: 1
Home Manager: Gus Malzahn Away Manager: Mike Houston
Head to Head
| NCAAF | 2020/09/26 16:00 | Central Florida v East Carolina | L | 51-28 |
| NCAAF | 2019/10/19 23:00 | East Carolina v Central Florida | L | 28-41 |
| NCAAF | 2018/10/20 23:00 | Central Florida v East Carolina | L | 37-10 |
| NCAAF | 2017/10/14 23:00 | Central Florida v East Carolina | L | 63-21 |
| NCAAF | 2016/10/01 16:00 | Central Florida v East Carolina | L | 47-29 |
| NCAAF | 2015/11/20 00:30 | Central Florida v East Carolina | W | 7-44 |
| NCAAF | 2014/12/05 00:30 | East Carolina v Central Florida | L | 30-32 |
| NCAAF | 2012/10/04 12:00 | Central Florida v East Carolina | L | 40-20 |
Home History
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | W | 28-31 |
| NCAAF | 2021/09/18 22:00 | East Carolina v Marshall | W | 42-38 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
Away History
| NCAAF | 2021/10/02 19:30 | Central Florida v Navy | L | 30-34 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | L | 35-42 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | W | 14-63 |
| NCAAF | 2021/09/02 23:00 | Boise State v Central Florida | W | 31-36 |
| NCAAF | 2020/12/23 00:00 | Central Florida v BYU | L | 23-49 |
| NCAAF | 2020/11/27 20:30 | Central Florida v South Florida | W | 58-46 |
| NCAAF | 2020/11/21 20:30 | Cincinnati v Central Florida | L | 36-33 |
| NCAAF | 2020/11/15 00:30 | Temple v Central Florida | W | 13-38 |