Estadio: Cajun Field Round: 1
Home Manager: Billy Napier Away Manager: Tim Rebowe
| NCAAF | 2011/09/17 12:00 | Lafayette v Nicholls Colonels | L | 38-21 |
| NCAAF | 2001/09/01 12:00 | Lafayette v Nicholls Colonels | L | 20-0 |
| NCAAF | 2021/09/04 23:00 | Nicholls Colonels v Memphis | L | 17-42 |
| NCAAF | 2021/04/10 20:00 | SE Louisiana Lions v Nicholls Colonels | L | 52-45 |
| NCAAF | 2021/04/03 17:00 | Nicholls Colonels v McNeese State Cowboys | L | 31-43 |
| NCAAF | 2021/03/27 16:00 | Incarnate Word v Nicholls Colonels | W | 45-75 |
| NCAAF | 2021/03/13 18:00 | Nicholls Colonels v Sam Houston State Bearkats | L | 17-71 |
| NCAAF | 2021/03/07 00:00 | Nicholls Colonels v Northwestern State | W | 31-24 |
| NCAAF | 2021/02/27 21:00 | Lamar Cardinals v Nicholls Colonels | W | 0-55 |
| NCAAF | 2021/02/20 00:00 | Nicholls Colonels v Lincoln University Blue Tigers | W | 87-3 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | L | 3-24 |
| NCAAF | 2021/09/04 20:30 | Lafayette v Texas | L | 18-38 |
| NCAAF | 2021/09/04 18:00 | Lafayette v Air Force | L | 14-35 |
| NCAAF | 2021/04/10 16:30 | Lehigh Mountain Hawks v Lafayette | W | 13-20 |
| NCAAF | 2021/03/27 20:00 | Lafayette v Bucknell | L | 13-38 |
| NCAAF | 2021/03/13 20:30 | Colgate v Lafayette | W | 10-24 |
| NCAAF | 2020/12/26 20:30 | Lafayette v Texas-San Antonio | W | 31-24 |
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | W | 24-21 |