[87] Duke 7-45 Wake Forest [7] 2021-10-30 20:00
Estadio: Allegacy Federal Credit Union Stadium Round: 1
Home Manager: Dave Clawson Away Manager: David Cutcliffe
Head to Head
| NCAAF | 2019/11/24 00:30 | Duke v Wake Forest | L | 27-39 |
| NCAAF | 2018/11/24 17:30 | Wake Forest v Duke | L | 59-7 |
| NCAAF | 2017/11/25 17:30 | Duke v Wake Forest | W | 31-23 |
| NCAAF | 2016/09/10 19:30 | Duke v Wake Forest | L | 14-24 |
| NCAAF | 2015/11/28 17:30 | Wake Forest v Duke | W | 21-27 |
| NCAAF | 2014/11/30 00:00 | Duke v Wake Forest | W | 41-21 |
| NCAAF | 2012/09/29 12:00 | Wake Forest v Duke | W | 27-34 |
| NCAAF | 2011/10/22 12:00 | Duke v Wake Forest | L | 23-24 |
Home History
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | L | 7-38 |
| NCAAF | 2021/09/25 20:00 | Kansas v Duke | W | 33-52 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
| NCAAF | 2021/09/11 00:00 | North Carolina A&T v Duke | W | 17-45 |
| NCAAF | 2021/09/03 23:00 | Duke v Charlotte | L | 28-31 |
| NCAAF | 2020/12/12 21:00 | Duke v Florida State | L | 35-56 |
Away History
| NCAAF | 2021/10/23 16:00 | Wake Forest v Army | W | 70-56 |
| NCAAF | 2021/10/09 19:30 | Wake Forest v Syracuse | W | 40-37 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | W | 34-37 |
| NCAAF | 2021/09/24 23:00 | Wake Forest v Virginia | W | 37-17 |
| NCAAF | 2021/09/18 19:30 | Florida State v Wake Forest | W | 14-35 |
| NCAAF | 2021/09/11 16:00 | Norfolk State Spartans v Wake Forest | W | 16-41 |
| NCAAF | 2021/09/03 23:00 | Old Dominion v Wake Forest | W | 10-42 |
| NCAAF | 2020/12/30 17:00 | Wisconsin v Wake Forest | L | 42-28 |