[11] Boston River 2-5 Peñarol [8] 2021-09-26 18:30
Estadio: Estadio Parque Artigas Round: 3
Árbitro: Daniel Fedorczuk Home Manager: Ignacio Ithurralde Away Manager: Jose Mauricio Larriera
Head to Head
| Uruguay - Torneo Apertura | 2021/05/30 21:00 | Peñarol v Boston River | L | 5-2 |
| Uruguay - Torneo Clausura | 2021/02/07 00:45 | Boston River v Peñarol | L | 1-2 |
| Uruguay - Torneo Intermedio | 2020/11/22 22:30 | Peñarol v Boston River | L | 2-0 |
| Uruguay - Torneo Apertura | 2020/08/16 20:30 | Peñarol v Boston River | L | 2-0 |
| Uruguay - Torneo Clausura | 2019/10/20 21:00 | Peñarol v Boston River | L | 1-0 |
| Uruguay - Torneo Intermedio | 2019/07/14 21:00 | Peñarol v Boston River | L | 4-0 |
| Uruguay - Torneo Apertura | 2019/03/30 22:00 | Boston River v Peñarol | L | 0-4 |
| Uruguay - Torneo Clausura | 2018/08/26 18:00 | Boston River v Peñarol | L | 1-2 |
Home History
| Uruguay - Torneo Clausura | 2021/09/17 18:30 | Rentistas v Boston River | W | 1-2 |
| Uruguay - Torneo Clausura | 2021/09/12 15:30 | Boston River v Montevideo Wanderers | L | 1-3 |
| Uruguay - Torneo Apertura | 2021/08/21 15:30 | Deportivo Maldonado v Boston River | W | 0-2 |
| Uruguay - Torneo Apertura | 2021/08/16 18:00 | Boston River v Centro Atlético Fénix | L | 0-2 |
| Uruguay - Torneo Apertura | 2021/08/09 18:00 | Plaza Colonia v Boston River | D | 0-0 |
| Uruguay - Torneo Apertura | 2021/07/31 18:00 | Boston River v IA Sud America | W | 2-0 |
| Uruguay - Torneo Apertura | 2021/07/16 18:00 | Club Atlético Progreso v Boston River | L | 1-0 |
| Uruguay - Torneo Apertura | 2021/07/11 15:15 | Boston River v Cerro Largo | W | 1-0 |
Away History
| Copa Sudamericana | 2021/09/24 00:30 | Peñarol v Athletico Paranaense | L | 1-2 |
| Uruguay - Torneo Clausura | 2021/09/17 23:00 | Peñarol v Centro Atlético Fénix | D | 0-0 |
| Uruguay - Torneo Clausura | 2021/09/12 18:30 | Plaza Colonia v Peñarol | W | 1-2 |
| Uruguay - Torneo Apertura | 2021/08/22 18:00 | IA Sud America v Peñarol | D | 1-1 |
| Copa Sudamericana | 2021/08/18 22:15 | Peñarol v Sporting Cristal | W | 1-0 |
| Uruguay - Torneo Apertura | 2021/08/14 22:00 | Peñarol v Club Atlético Progreso | W | 1-0 |
| Copa Sudamericana | 2021/08/11 22:15 | Sporting Cristal v Peñarol | W | 1-3 |
| Uruguay - Torneo Apertura | 2021/08/06 21:00 | Cerro Largo v Peñarol | W | 0-1 |