[16] Khonkaen 0-0 Ayutthaya United [10] 2021-11-28 11:00
Estadio: Khon Kaen Sports Stadium Round: 16
Home Manager: Miura Masayuki Away Manager: Anurak Srikerd
Head to Head
| Tailandia - 2ª División | 2021/03/21 12:00 | Ayutthaya United v Khonkaen | W | 1-2 |
| Tailandia - 2ª División | 2020/11/28 12:00 | Khonkaen v Ayutthaya United | L | 1-3 |
| Tailandia - 2ª División | 2019/07/14 11:00 | Ayutthaya United v Khonkaen | D | 0-0 |
| Tailandia - 2ª División | 2019/03/02 13:00 | Khonkaen v Ayutthaya United | W | 3-2 |
| Tailandia - 3ª División | 2017/08/06 11:30 | Ayutthaya United v Khonkaen | D | 1-1 |
| Tailandia - 3ª División | 2017/04/01 10:25 | Khonkaen v Ayutthaya United | W | 2-1 |
| Tailandia - Copa de la Liga | 2017/03/01 11:00 | Ayutthaya United v Khonkaen | L | 4-1 |
Home History
| Tailandia - 2ª División | 2021/11/20 12:00 | Udon Thani FC v Khonkaen | L | 4-1 |
| Tailandia - 2ª División | 2021/11/17 10:00 | Khonkaen v Royal Navy | W | 3-1 |
| Tailandia - 2ª División | 2021/11/14 11:00 | Raj Pracha v Khonkaen | L | 2-0 |
| Tailandia - 2ª División | 2021/11/07 11:00 | Khonkaen v Trat FC | D | 1-1 |
| Tailandia - Copa de la Liga | 2021/11/03 08:00 | Nakhon Ratchasima United v Khonkaen | L | 2-1 |
| Tailandia - 2ª División | 2021/10/30 11:30 | Rayong FC v Khonkaen | L | 3-1 |
| Copa de Tailandia | 2021/10/27 10:00 | Khonkaen v Bangkok United | L | 0-3 |
| Tailandia - 2ª División | 2021/10/23 10:00 | Khonkaen v Lampang FC | L | 1-3 |
Away History
| Tailandia - 2ª División | 2021/11/20 11:00 | Ayutthaya United v Lamphun Warrior FC | D | 1-1 |
| Tailandia - 2ª División | 2021/11/17 10:00 | Kasetsart FC v Ayutthaya United | W | 0-2 |
| Tailandia - 2ª División | 2021/11/13 11:00 | Ayutthaya United v Customs United | D | 1-1 |
| Tailandia - 2ª División | 2021/11/06 11:00 | Ayutthaya United v Rayong FC | W | 1-0 |
| Tailandia - 2ª División | 2021/10/30 12:00 | Udon Thani FC v Ayutthaya United | L | 1-0 |
| Tailandia - 2ª División | 2021/10/24 11:00 | Ayutthaya United v Raj Pracha | W | 2-0 |
| Tailandia - 2ª División | 2021/10/16 12:00 | Lampang FC v Ayutthaya United | L | 3-0 |
| Tailandia - 2ª División | 2021/10/13 11:30 | Ayutthaya United v Royal Navy | W | 4-0 |