[1] São Paulo 1-0 Ayacucho FC [3] 2022-05-25 22:15
Estadio: Estadio Morumbí Round: 6
Árbitro: Carlos P. Benitez Home Manager: Rogério Ceni Away Manager: Alejandro Apud
Head to Head
| Copa Sudamericana | 2022/04/08 00:30 | Ayacucho FC v São Paulo | W | 2-3 |
Home History
| Brasil - Serie A | 2022/05/22 19:00 | Corinthians v São Paulo | D | 1-1 |
| Copa Sudamericana | 2022/05/20 00:30 | São Paulo v Jorge Wilstermann | W | 3-0 |
| Brasil - Serie A | 2022/05/15 19:00 | São Paulo v Cuiabá | W | 2-1 |
| Copa do Brasil | 2022/05/12 22:30 | São Paulo v EC Juventude | W | 2-0 |
| Brasil - Serie A | 2022/05/08 22:00 | Fortaleza EC v São Paulo | D | 1-1 |
| Copa Sudamericana | 2022/05/05 22:15 | Everton de Viña del Mar v São Paulo | D | 0-0 |
| Brasil - Serie A | 2022/05/02 23:00 | São Paulo v Santos | W | 2-1 |
| Copa Sudamericana | 2022/04/28 22:15 | Jorge Wilstermann v São Paulo | W | 1-3 |
Away History
| Perú - Liga 1 | 2022/05/22 20:30 | Ayacucho FC v FBC Melgar | L | 0-1 |
| Copa Sudamericana | 2022/05/18 22:15 | Ayacucho FC v Everton de Viña del Mar | L | 0-2 |
| Perú - Liga 1 | 2022/05/13 18:15 | Sporting Cristal v Ayacucho FC | L | 3-2 |
| Perú - Liga 1 | 2022/05/08 20:30 | Ayacucho FC v Carlos Manucci | D | 2-2 |
| Copa Sudamericana | 2022/05/06 00:30 | Ayacucho FC v Jorge Wilstermann | D | 0-0 |
| Perú - Liga 1 | 2022/05/01 16:00 | Alianza Atletico v Ayacucho FC | L | 2-1 |
| Copa Sudamericana | 2022/04/27 00:30 | Everton de Viña del Mar v Ayacucho FC | L | 2-1 |
| Perú - Liga 1 | 2022/04/22 20:30 | Ayacucho FC v Atlético Grau | L | 1-2 |