Round: 1
| NCAAF | 2021/11/06 21:00 | Savannah State v Edward Waters Tigers | L | 24-0 |
| NCAAF | 2021/10/30 22:00 | Edward Waters Tigers v Miles Golden Bears | L | 9-16 |
| NCAAF | 2021/10/23 18:00 | Edward Waters Tigers v Central State | W | 56-19 |
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky State University Thorobreds | L | 36-76 |
| NCAAF | 2021/10/09 18:00 | Albany State Golden Rams v Edward Waters Tigers | L | 30-0 |
| NCAAF | 2021/10/02 18:00 | Morehouse College Maroon Tigers v Edward Waters Tigers | W | 13-37 |
| NCAAF | 2021/09/25 22:00 | Edward Waters Tigers v Lane College Dragons | L | 35-45 |
| NCAAF | 2021/09/09 23:30 | Benedict College v Edward Waters Tigers | L | 44-3 |