[5] Club América 1-0 Santos Laguna [2] 2018-04-29 02:00
Clima: Bueno Estadio: Estadio Azteca Campo: Bueno Round: 17
Árbitro: Adonai Escobedo Gonzalez Home Manager: Miguel Herrera Away Manager: Robert Siboldi
Head to Head
| México - Liga MX | 2017/11/20 00:30 | Santos Laguna v Club América | W | 0-1 |
| Europa - Amistosos | 2017/07/06 01:30 | Club América v Santos Laguna | W | 3-2 |
| México - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club América | L | 2-1 |
| México - Copa MX | 2017/03/02 02:30 | Santos Laguna v Club América | L | 2-1 |
| México - Copa MX | 2017/01/19 02:30 | Club América v Santos Laguna | W | 3-2 |
| México - Liga MX | 2016/10/30 02:00 | Club América v Santos Laguna | W | 3-1 |
| CONCACAF - Copa de Campeones | 2016/04/06 02:00 | Club América v Santos Laguna | W | 1-0 |
| CONCACAF - Copa de Campeones | 2016/03/17 02:00 | Santos Laguna v Club América | D | 0-0 |
Home History
| México - Liga MX | 2018/04/21 00:00 | Puebla v Club América | L | 3-1 |
| México - Liga MX | 2018/04/15 02:00 | Club América v Monterrey | D | 0-0 |
| CONCACAF - Copa de Campeones | 2018/04/11 02:00 | Club América v Toronto FC | D | 1-1 |
| México - Liga MX | 2018/04/08 02:00 | Necaxa v Club América | D | 1-1 |
| CONCACAF - Copa de Campeones | 2018/04/04 00:00 | Toronto FC v Club América | L | 3-1 |
| México - Liga MX | 2018/04/01 03:00 | Club América v Cruz Azul | W | 2-1 |
| Clubes del Mundo - Amistosos | 2018/03/24 23:30 | Club América v Tijuana | D | 2-2 |
| México - Liga MX | 2018/03/18 03:00 | Club América v Toluca | L | 1-2 |
Away History
| México - Liga MX | 2018/04/22 23:00 | Santos Laguna v Pumas de la UNAM | L | 1-2 |
| México - Liga MX | 2018/04/15 00:06 | Pachuca v Santos Laguna | L | 3-1 |
| México - Liga MX | 2018/04/08 23:00 | Santos Laguna v Querétaro | W | 3-0 |
| México - Copa MX | 2018/04/05 02:15 | Necaxa v Santos Laguna | L | 2-1 |
| México - Liga MX | 2018/03/31 03:00 | Atlas v Santos Laguna | L | 3-2 |
| México - Liga MX | 2018/03/17 01:00 | Puebla v Santos Laguna | W | 0-1 |
| México - Copa MX | 2018/03/14 03:15 | Santos Laguna v Querétaro | W | 1-0 |
| México - Liga MX | 2018/03/12 00:00 | Santos Laguna v Monterrey | W | 3-2 |