Estadio: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Gary Goff
| NCAAF | 2022/10/30 00:00 | SE Louisiana Lions v McNeese State Cowboys | L | 28-27 |
| NCAAF | 2021/10/30 23:00 | McNeese State Cowboys v SE Louisiana Lions | L | 20-23 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana Lions v McNeese State Cowboys | L | 38-35 |
| NCAAF | 2021/03/07 00:00 | McNeese State Cowboys v SE Louisiana Lions | L | 20-25 |
| NCAAF | 2019/10/05 21:00 | SE Louisiana Lions v McNeese State Cowboys | W | 34-38 |
| NCAAF FCS | 2018/11/03 19:30 | McNeese State Cowboys v SE Louisiana Lions | L | 6-23 |
| NCAAF | 2017/11/04 23:00 | McNeese State Cowboys v SE Louisiana Lions | W | 13-3 |
| NCAAF | 2023/10/22 00:00 | Incarnate Word v McNeese State Cowboys | L | 35-24 |
| NCAAF | 2023/10/08 00:00 | McNeese State Cowboys v Texas A&M-Commerce | L | 10-41 |
| NCAAF | 2023/10/01 00:00 | Nicholls Colonels v McNeese State Cowboys | L | 31-10 |
| NCAAF | 2023/09/23 19:00 | McNeese State Cowboys v Eastern Illinois | L | 28-31 |
| NCAAF | 2023/09/16 23:00 | McNeese State Cowboys v Alcorn State | L | 3-17 |
| NCAAF | 2023/09/09 23:30 | McNeese State Cowboys v Florida | L | 7-49 |
| NCAAF | 2023/09/03 00:00 | Tarleton State v McNeese State Cowboys | L | 52-34 |
| NCAAF | 2022/11/20 01:00 | Lamar Cardinals v McNeese State Cowboys | W | 20-24 |
| NCAAF | 2023/10/20 00:00 | SE Louisiana Lions v Northwestern State | W | 37-20 |
| NCAAF | 2023/10/14 20:00 | Lamar Cardinals v SE Louisiana Lions | L | 30-24 |
| NCAAF | 2023/10/07 21:00 | SE Louisiana Lions v Incarnate Word | L | 26-33 |
| NCAAF | 2023/09/30 20:00 | Tarleton State v SE Louisiana Lions | L | 14-13 |
| NCAAF | 2023/09/23 23:00 | Houston Christian v SE Louisiana Lions | L | 34-19 |
| NCAAF | 2023/09/16 20:00 | SE Louisiana Lions v East Washington | L | 29-40 |
| NCAAF | 2023/09/09 21:00 | SE Louisiana Lions v South Alabama | L | 17-35 |
| NCAAF | 2023/09/02 20:00 | SE Louisiana Lions v Mississippi State | L | 7-48 |