[2] Club América 2-2 Santos Laguna [4] 2018-05-14 00:00
Clima: Bueno Estadio: Estadio Azteca Campo: Bueno Round: 2
Árbitro: Jorge Perez Home Manager: Miguel Herrera Away Manager: Robert Siboldi
Head to Head
| México - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | L | 4-1 |
| México - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | W | 1-0 |
| México - Liga MX | 2017/11/20 00:30 | Santos Laguna v Club América | W | 0-1 |
| Europa - Amistosos | 2017/07/06 01:30 | Club América v Santos Laguna | W | 3-2 |
| México - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club América | L | 2-1 |
| México - Copa MX | 2017/03/02 02:30 | Santos Laguna v Club América | L | 2-1 |
| México - Copa MX | 2017/01/19 02:30 | Club América v Santos Laguna | W | 3-2 |
| México - Liga MX | 2016/10/30 02:00 | Club América v Santos Laguna | W | 3-1 |
Home History
| México - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | L | 4-1 |
| México - Liga MX | 2018/05/06 00:00 | Club América v Pumas de la UNAM | W | 2-1 |
| México - Liga MX | 2018/05/03 00:30 | Pumas de la UNAM v Club América | W | 1-4 |
| México - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | W | 1-0 |
| México - Liga MX | 2018/04/21 00:00 | Puebla v Club América | L | 3-1 |
| México - Liga MX | 2018/04/15 02:00 | Club América v Monterrey | D | 0-0 |
| CONCACAF - Copa de Campeones | 2018/04/11 02:00 | Club América v Toronto FC | D | 1-1 |
| México - Liga MX | 2018/04/08 02:00 | Necaxa v Club América | D | 1-1 |
Away History
| México - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | W | 4-1 |
| México - Liga MX | 2018/05/06 23:00 | Santos Laguna v Tigres UANL | W | 2-0 |
| México - Liga MX | 2018/05/04 00:30 | Tigres UANL v Santos Laguna | L | 2-0 |
| México - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | L | 1-0 |
| México - Liga MX | 2018/04/22 23:00 | Santos Laguna v Pumas de la UNAM | L | 1-2 |
| México - Liga MX | 2018/04/15 00:06 | Pachuca v Santos Laguna | L | 3-1 |
| México - Liga MX | 2018/04/08 23:00 | Santos Laguna v Querétaro | W | 3-0 |
| México - Copa MX | 2018/04/05 02:15 | Necaxa v Santos Laguna | L | 2-1 |