[9] Melipilla 1-0 Club Deportes Santa Cruz [15] 2022-05-22 21:30
Estadio: Municipal Roberto Bravo Round: 16
Head to Head
| Chile - Primera B | 2020/12/23 23:30 | Melipilla v Club Deportes Santa Cruz | D | 0-0 |
| Chile - Primera B | 2020/08/31 19:00 | Club Deportes Santa Cruz v Melipilla | W | 2-4 |
| Chile - Primera B | 2019/09/29 20:00 | Melipilla v Club Deportes Santa Cruz | D | 2-2 |
| Chile - Primera B | 2019/05/18 22:00 | Club Deportes Santa Cruz v Melipilla | L | 1-0 |
| Chile - Segunda División | 2017/10/18 21:59 | Club Deportes Santa Cruz v Melipilla | L | 2-1 |
| Chile - Segunda División | 2017/08/16 22:02 | Melipilla v Club Deportes Santa Cruz | L | 2-3 |
| Chile - Segunda División | 2017/04/15 22:00 | Club Deportes Santa Cruz v Melipilla | L | 1-0 |
| Chile - Segunda División | 2017/01/14 22:02 | Melipilla v Club Deportes Santa Cruz | W | 3-0 |