| México - Liga sub-23 | 04/28 17:30 | 17 | [13] Santos Laguna sub-23 v Atlético de San Luis sub-23 [3] | L | 0-3 | |
| México - Liga sub-23 | 04/21 17:00 | 16 | [16] Santos Laguna sub-23 v Pachuca sub-23 [3] | W | 2-1 | |
| México - Liga sub-23 | 04/12 15:00 | 15 | [1] Club Necaxa sub-23 v Santos Laguna sub-23 [13] | L | 2-1 | |
| México - Liga sub-23 | 04/06 17:00 | 14 | Santos Laguna sub-23 v Club América sub-23 | L | 0-2 | |
| México - Liga sub-23 | 03/31 15:00 | 13 | [7] Juárez FC sub-23 v Santos Laguna sub-23 [12] | L | 2-0 | |
| México - Liga sub-23 | 03/15 23:45 | 12 | [18] Tijuana sub-23 v Santos Laguna sub-23 [13] | W | 1-5 | |
| México - Liga sub-23 | 03/09 17:00 | 11 | [11] Santos Laguna sub-23 v Cruz Azul sub-23 [4] | D | 1-1 | |
| México - Liga sub-23 | 03/01 15:00 | 10 | [17] Querétaro sub-23 v Santos Laguna sub-23 [9] | L | 5-1 | |
| México - Liga sub-23 | 02/25 17:00 | 8 | [12] Santos Laguna sub-23 v Mazatlán FC sub-23 [15] | W | 3-0 | |
| México - Liga sub-23 | 02/21 15:00 | 9 | [7] Toluca sub-23 v Santos Laguna sub-23 [14] | D | 0-0 | |
| México - Liga sub-23 | 02/18 15:00 | 7 | [15] Pumas de la UNAM sub-23 v Santos Laguna sub-23 [11] | L | 3-0 | |
| México - Liga sub-23 | 02/10 17:00 | 6 | [10] Santos Laguna sub-23 v Tigres UANL sub-23 [3] | D | 1-1 |
| Total | Local | Visitante | |
|---|---|---|---|
| Encuentros Disputados | 36 | 18 | 18 |
| Wins | 12 | 9 | 3 |
| Draws | 8 | 5 | 3 |
| Losses | 16 | 4 | 12 |
| Goals for | 57 | 32 | 25 |
| Goals against | 61 | 20 | 41 |
| Clean sheets | 8 | 6 | 2 |
| Failed to score | 10 | 5 | 5 |