| NCAAF | 11/18 19:00 | 1 | South Dakota v Western Illinois | L | 48-6 | |
| NCAAF | 11/11 18:00 | 1 | Western Illinois v Indiana State | L | 6-27 | |
| NCAAF | 11/04 18:00 | 1 | Western Illinois v Northern Iowa Panthers | L | 6-50 | |
| NCAAF | 10/28 20:00 | 1 | Southern Illinois Salukis v Western Illinois | L | 63-0 | |
| NCAAF | 10/21 19:30 | 1 | Western Illinois v North Dakota State | L | 7-52 | |
| NCAAF | 10/14 20:00 | 1 | Missouri State v Western Illinois | L | 48-7 | |
| NCAAF | 10/07 18:00 | 1 | Western Illinois v North Dakota | L | 10-49 | |
| NCAAF | 09/24 00:00 | 1 | Western Illinois v Southern Utah Thunderbirds | L | 17-37 | |
| NCAAF | 09/16 23:00 | 1 | Lindenwood v Western Illinois | L | 43-40 | |
| NCAAF | 09/09 20:00 | 1 | Illinois State v Western Illinois | L | 34-18 | |
| NCAAF | 09/03 01:00 | 1 |
[32] Western Illinois
v
New Mexico State
[112] 
|
L | 21-58 | |
| NCAAF | 11/19 17:00 | 1 | Western Illinois v Illinois State | L | 13-20 | |
| NCAAF | 11/12 19:00 | 1 | Indiana State v Western Illinois | L | 21-0 | |
| NCAAF | 11/05 18:00 | 1 | North Dakota State v Western Illinois | L | 56-17 | |
| NCAAF | 10/29 19:00 | 1 | Western Illinois v Missouri State | L | 14-64 | |
| NCAAF | 10/22 20:00 | 1 | Youngstown State v Western Illinois | L | 28-27 | |
| NCAAF | 10/15 19:00 | 1 | Western Illinois v Southern Illinois Salukis | L | 7-30 | |
| NCAAF | 10/01 19:00 | 1 | Western Illinois v South Dakota State | L | 10-34 | |
| NCAAF | 09/24 20:00 | 1 | Northern Iowa Panthers v Western Illinois | L | 52-17 | |
| NCAAF | 09/17 20:00 | 1 | Southern Utah Thunderbirds v Western Illinois | L | 17-10 | |
| NCAAF | 09/10 16:00 | 1 |
[80] Western Illinois
v
Minnesota
[7] 
|
L | 10-62 | |
| NCAAF | 09/01 23:30 | 1 | Western Illinois v Tennessee Martin | L | 25-42 | |
| NCAAF | 11/20 19:00 | 1 | Western Illinois v Northern Iowa Panthers | L | 3-41 | |
| NCAAF | 11/06 17:00 | 1 | South Dakota v Western Illinois | L | 42-21 | |
| NCAAF | 10/30 20:00 | 1 | Illinois State v Western Illinois | W | 31-38 | |
| NCAAF | 10/23 19:00 | 1 | Western Illinois v North Dakota | L | 10-34 | |
| NCAAF | 10/16 17:00 | 1 | South Dakota State v Western Illinois | L | 41-17 | |
| NCAAF | 10/09 17:00 | 1 | Western Illinois v Indiana State | L | 27-37 | |
| NCAAF | 10/02 20:00 | 1 | Southern Illinois Salukis v Western Illinois | L | 31-30 | |
| NCAAF | 09/25 22:00 | 1 | [108] Western Illinois v Youngstown State [58] | W | 38-35 |