[12] PHI Flyers 3-6 BUF Sabres [6] 2022-01-22 18:00
Estadio: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Yeo
Head to Head
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
| NHL | 2021/01/19 00:30 | BUF Sabres v PHI Flyers | L | 6-1 |
Home History
| NHL | 2022/01/21 00:00 | CLB Blue Jackets v PHI Flyers | L | 2-1 |
| NHL | 2022/01/19 00:00 | NY Islanders v PHI Flyers | L | 4-3 |
| NHL | 2022/01/18 00:30 | PHI Flyers v NY Islanders | L | 1-4 |
| NHL | 2022/01/16 00:00 | NY Rangers v PHI Flyers | L | 3-2 |
| NHL | 2022/01/14 00:00 | PHI Flyers v BOS Bruins | L | 2-3 |
| NHL | 2022/01/09 00:00 | SJ Sharks v PHI Flyers | L | 3-2 |
| NHL | 2022/01/07 00:00 | PIT Penguins v PHI Flyers | L | 6-2 |
| NHL | 2022/01/05 03:00 | PHI Flyers v ANA Ducks | L | 1-4 |
Away History
| NHL | 2022/01/21 00:00 | DAL Stars v BUF Sabres | L | 5-4 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | L | 3-2 |
| NHL | 2022/01/16 00:00 | BUF Sabres v DET Red Wings | L | 0-4 |
| NHL | 2022/01/14 01:00 | BUF Sabres v NAS Predators | W | 4-1 |
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |